Twitter Weekly Updates for 2009-11-22

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Twitter Weekly Updates for 2009-11-15

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Twitter Weekly Updates for 2009-11-08

  • RT @jjmorin:i needed a wall to lean on for a quick drink one day, just some wall http://twitpic.com/oohui < nice piece of history there #
  • RT @jonmcculloch:"Oh look, some fossils! Looks like they are really old. Close my eyes to facts". — Creationist Haiku #
  • RT @jjmorin:crazy women's soccer http://post.ly/BxOj < I thought men's soccer got rough – that was like watching a street fight … #
  • @clarkjf – I had just had a conversation over lunch on the abuse of P-val in bioscience lit w/friend – this was quite amusing to read in reply to clarkjf #
  • Hector off to open studios with KBH and then joining Lily and Janet (?) for dinner. going to be a great night! http://ff.im/b6v0k #
  • RT @phylogenomics:@andyfell Anyone w/any interest in how science is reported should read this excellent discu of p value http://bit.ly/jnCio #
  • RT @sciencebase:Scientists vs Researchers http://bit.ly/geh8a < very good explanation of differences between both groups #
  • @BobOHara – wasn't there that paper this week which said multi-taskers were actually worse off that others? I guess this will teach them .. in reply to BobOHara #
  • RT @scicurious:"fishless oceans" would be a great name for an emo band. < that is pretty good … #
  • RT @MyMarrakesh:firm I work for as a democracy & human rights specialist:just awarded 1 of top 5 US contractors for excellence. So proud:-) #
  • A new Latin American #tapas restaurant, #Congas, Opens Today in #Harvard Square. @hiddenboston http://bit.ly/2VWQRh #
  • Hector is making flan for group meeting tomorrow, drinking wine, and catching up on 4 weeks of Science Magazine…. http://ff.im/b3JsO #
  • @Comprendia – I remember him answering my e-mails as a graduate student – that meant a lot to me – he was very thoughtful and helpful to all in reply to Comprendia #
  • @LDGourmet – yeah they are – I love the short, fun articles in Scientific American – Science magazine as short and almost as much fun in reply to LDGourmet #
  • @Comprendia – I hear the news earlier – the xtallography and structural biology community will miss him a lot – RIP in reply to Comprendia #
  • Drinking wine, making flan for group meeting tomorrow, & catching up on 4 weeks of Science magazine. What a way to spend Thursday night :-) #
  • RT @VivianBoroff:Trying to not look at the news right now :( . #depressing < it has been one of those weeks … #
  • RT @phylogenomics:OMG the best paper in years – http://isotropic.org/papers/chicken.pdf – HT to Jessica Green pointing… http://ff.im/b1NPs #
  • RT @MicrobeWorld:Home Researchers study bacteria’s use in solar energy:in the future, bact could harness solar energy.. http://bit.ly/3vUAfK #
  • @AngelinaSouren – a fun way to raise awareness and money for testicular/prostate cancer research – http://us.movember.com/about/ in reply to AngelinaSouren #
  • RT @HarvardResearch:Industry support of academic life science research may be declining http://ow.ly/zglB #
  • Laptop Steering Wheel Desk – ? – amazing stupid ideas – make sure to read the reviews – http://bit.ly/4xeztd #
  • Reading 'Havana Salsa: Stories & Recipes' by Viviana Carballo – reminds me of growing up and listening to my grandfather's stories of #Cuba #
  • RT @BoraZ:Leonard Cohen http://tinyurl.com/ycwnjsy at @DPAC last night…. < so jealous … #
  • RT @bstockwell:Interesting article:@sgruenwald:Harvard business school: Two lists you should look @ every morning http://tinyurl.com/yayz6ks #
  • RT @anitaborg_org:i'm still working on my list but here's the work in progress @anitaborg_org/tech-women2follow #women2follow #
  • RT @MassHighTech:@missusP: Know a wicked smart lady? Nominate her: MHT's Women2Watch (Deadline 12/4) http://bit.ly/3QwMGc #women #leadership #
  • RT @craigieonmain:Craigie Cocktail Whim (4 mini drinks for $20). After 10, u can talk shop w bartenders.Techniques & secrets of revealed. #
  • Immigrants, minorities, GBLT, your country rejects you – America has become the land of bigotry, hate, and oppression – 2/2 #
  • Maine Voters Repeal Law Allowing Gay Marriage – another sad day for America – we should be ashamed of our actions 1/2 – http://bit.ly/2nHpnl #
  • RT @kbherman:waiting on Maine on 1 – you and me both. #
  • RT @gregladen:Prayer as medicine to be included in Health Care Reform http://bit.ly/2IQKeD < WTF! #
  • RT @lotuspad:@mmcgovern:@brainpicker: Fast Company's list of 12 of the world's #coolest packaging #designs http://is.gd/4Mk4x #
  • RT @blackaller:Ya me voy a comerme un BLT en Emma's Pizza http://www.emmaspizz con @hhhernandez – estuvo de maravillas – una buena decision #
  • @AngelinaSouren – yeah, we're doing #Movember here in Parsons Lab and I figures I needed a 'clean' new look :-) in reply to AngelinaSouren #
  • @sciencebase – any chance online publishers provide more complete content coverage? No printing / limited space costs 2/2 in reply to sciencebase #
  • RT @sciencebase:My Whole Cell Twitter Interview: http://bit.ly/Em0Eq < it is too bad journal article interviews are space limited 1/2 #
  • Wall of Sound. Weighing a sumo-esque120 kg, has tube amp & 28 elements, handcrafted box, 125W of sound, 3 x 4' frame http://bit.ly/1QIAV2 #
  • Scientist proposes "cyborg astrobiologists" astronauts to seek out new life – http://bit.ly/2×1tGr #
  • Rolltop touchscreen laptop concept designed to save the news – pretty cool concept – http://bit.ly/2LemJr #
  • Ray Wu Agricultural Technology Innovation Center at #Cornell – bring CU agricultural innovations to #Chinahttp://bit.ly/21043a #
  • #LBNL – Berkeley Lab Receives $7 Million for Enhanced #Geothermal #Energy Technologies – http://bit.ly/21LnDO #
  • #Movember – Changing the face of men's health one moustache at a time -http://us.movember.com/mospace/294098 #
  • @SteveCadwell – Mozart's Horn Concertos? Have a particular fondness of french horns. #fb in reply to SteveCadwell #
  • Beautiful moon on the way in. Sunlight reflected on the Hankcock. Going to be a good one. #
  • RT @crispysea:RT @Monicks: Be proud of being an #atheist, set an example! #atheism #atheist #
  • RT @thequeenoftarts:Olive Bread in the oven… hopefully it will turn out alright! < it was more than alright – modif @zoebakes buttrmlk brd #
  • RT @APerronHasHeart:The leaders elected Tuesday will have a noticeable impact on our lives. Remember every vote does make a difference. #
  • RT @jennifurret:Purdue Professor: #Gays wasting our money on #AIDS research: Multiple #Purdue students have alerted me.. http://bit.ly/e2fQg #
  • RT @MicrobeWorld:An Epidemic of Fear: How Panicked Parents Skipping Shots Endangers Us All: Amy Wallace, freelance … http://bit.ly/4ifY6 #
  • RT @CambridgeCarrie:new fall cocktail menu, seth's 1974 (@ Trina's Starlite Lounge in Somerville) – http://bit.ly/1s5Pnq #
  • @AngelinaSouren – All I have to do is read the next issue of Emerging Infectious Diseases by the CDC – http://bit.ly/33YCgC in reply to AngelinaSouren #
  • RT @dowwhiz:Nature has an amazing way of controlling population growth through new and ever changing diseases. #
  • Looking for chocolate molds – any preferences out there? The yearly holiday party coming along soon … #
  • RT @BoraZ:Top Twitter Lists http://tinyurl.com/yf9v4w8 very male…let's make a women-in-STEM and/or women-bloggers lists & such & push them #
  • RT @HarvardResearch:Young #women who have migraines with auras are twice as likely to have a #stroke http://ow.ly/x3mN #
  • RT @blackaller:I have two memories. One is biological, and unreliable. The other is digital, and unreliable. < te escucho … #
  • @zoebakes – looking at the Tapenade (pg 55) or the Buttermilk breads (pg 207) – maybe @thequeenoftarts and I will make both! in reply to zoebakes #
  • Just got back from a nice overnight in the country with @thequeenoftarts – deciding what to bake, maybe a loaf that goes with my home brew #

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Twitter Weekly Updates for 2009-11-01

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Twitter Weekly Updates for 2009-11-01

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Center for Alternative Technology – Paul Allen

Last Friday, Paul Allen from the Centre for Alternative Technology (CAT) in Machynlleth Mid-Wales spoke about the centers work during seminar in the Parson’s Lab.  He is the CAT Development Director and co-author of the Zero Carbon Britain (ZCB) report. Mr. Allen has spent the last month traveling the US from the East Coast to the West Coast by train giving his presentation about the CAT and the ZCB initiative.

The CAT advocates for an environmental policy that integrates current and emerging environmental management practices, new technology, and education to promote sustainable living communities.  Recently they partnered with University of East London to offer graduate programs in Architecture specializing in Environmental and Energy Studies, Renewable energy in the Built Environment, and Ecological Building Practices.  Mr. Allen’s work with CAT and the ZCB report is providing a policy and lifestyle framework which if adopted, can lower their dependency on fossil fuels and imported energy taking Britain a long way on the road to zero carbon emissions and energy independence.  Along the way, I hope they can provide a successful, sustainable environmental management model that can be used by other developed nations.  If you are interested in finding out more about the CAT, make sure to visit them online.

Twitter Weekly Updates for 2009-09-13

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Twitter Weekly Updates for 2009-09-06

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Twitter Weekly Updates for 2009-08-30

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Thermoplasma acidophilum -a model organism to study iron stress in microbes?

Thermoplasma acidophilum. Linda Stannard, UCT/Photo Science Library.Microbes require iron (Fe) as an essential element for growth and development.  It has two environmentally stable oxidation states (II and III) readily participating in redox reactions covering a wide magnitude of biological electron transport and redox reactions including respiration, oxygen activation and binding, degradation of peroxides and superoxides, synthesis of DNA, proteins, and other organic molecules, and energy fixation pathways.  At the same time, unregulated iron uptake can lead to toxicity, reactive oxygen species (ROS) and to inhibition of growth.

Microbes have evolved an iron storage mechanism used to store iron under limiting or environmental stress.  The most studied system is that in Escherichia coli which produces three structurally and chemically related storage proteins; ferritins, bacterioferritins, and Dps (DNA-binding proteins during stationary phase).  Ferritin and bacterioferritin are a tetracosameric structures capable of storing 2,500 and 1,800 iron atoms respectively. Bacterioferritin differs from ferritins in that they have an iron protoporphyrin IX (heme) at the interphase of each subunit.  Dps is a dodecameric ferritin, which is induced under stationary phase of growth or by oxidative stress.  These supramolecular structures help sequester iron in the cytoplasm and prevent toxicity of free iron in the cytoplasm.

Microbes living in low pH environments are subject to high concentrations of metals, in particular iron.  How these microbes respond to metal stress is key to understanding how organisms control energy producing metabolic reactions in the cell.  Recently, the genome of T. acidophilum was completed affording us a glimpse of the possible biochemical pathways responsible for the survival of this organism in an acidic environment, but analysis of the T. acidophilum genome did not reveal any molecular pathways for the production of known iron storage proteins ferritin, bacterioferritin, or Dps.

How does T. acidophilum manage the high concentrations of soluble iron, or other metals, liberated by its acidic environment?  Does this organism have a novel iron storage mechanism?   What are the cellular responses to stress to T. acidophilum cause by high metal concentration in the cytoplasm or by ROS?  This is one of the questions that I am trying to answer using transcriptomics to look at differential gene expression of this Archeaon under varying iron and other  environmental stress conditions.